Ontology highlight
ABSTRACT:
SUBMITTER: Juraver-Geslin HA
PROVIDER: S-EPMC3038765 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Juraver-Geslin Hugo A HA Ausseil Jérome J JJ Wassef Marion M Durand Béatrice C BC
Proceedings of the National Academy of Sciences of the United States of America 20110124 6
Little is known about the respective contributions of cell proliferation and cell death to the control of vertebrate forebrain growth. The homeodomain protein barhl2 is expressed in the diencephalons of Xenopus, zebrafish, and mouse embryos, and we previously showed that Barhl2 overexpression in Xenopus neuroepithelial cells induces Caspase3-dependent apoptosis. Here, barhl2 is shown to act as a brake on diencephalic proliferation through an unconventional function of Caspase3. Depletion of Barh ...[more]