Ontology highlight
ABSTRACT:
SUBMITTER: Aich U
PROVIDER: S-EPMC3038847 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Aich Udayanath U Meledeo M Adam MA Sampathkumar Srinivasa-Gopalan SG Fu Jie J Jones Mark B MB Weier Christopher A CA Chung Sung Yun SY Tang Benjamin C BC Yang Ming M Hanes Justin J Yarema Kevin J KJ
Glycoconjugate journal 20100511 4
Carbohydrates are attractive candidates for drug development because sugars are involved in many, if not most, complex human diseases including cancer, immune dysfunction, congenital disorders, and infectious diseases. Unfortunately, potential therapeutic benefits of sugar-based drugs are offset by poor pharmacologic properties that include rapid serum clearance, poor cellular uptake, and relatively high concentrations required for efficacy. To address these issues, pilot studies are reported he ...[more]