Ontology highlight
ABSTRACT:
SUBMITTER: O'Keefe DD
PROVIDER: S-EPMC3039039 | biostudies-literature | 2011 Jan-Feb
REPOSITORIES: biostudies-literature
O'Keefe David D DD Edgar Bruce A BA Saucedo Leslie J LJ
Mechanisms of development 20101103 1-2
Signaling through the Notch receptor has dramatically different effects depending on cell type and developmental timing. While a myriad of biological systems affected by Notch have been described, the molecular mechanisms by which a generic Notch signal is translated into a cell-type-specific output are less clear. Canonically, the Notch intracellular domain (NICD) translocates into the nucleus upon ligand binding to transcriptionally regulate target genes. In order to generate specificity, ther ...[more]