Serine phosphoacceptor sites within the core protein of hepatitis B virus contribute to genome replication pleiotropically.
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ABSTRACT:
SUBMITTER: Lewellyn EB
PROVIDER: S-EPMC3039676 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
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Serine phosphoacceptor sites within the core protein of hepatitis B virus contribute to genome replication pleiotropically.
Lewellyn Eric B EB Loeb Daniel D DD
PloS one 20110215 2
The core protein of hepatitis B virus can be phosphorylated at serines 155, 162, and 170. The contribution of these serine residues to DNA synthesis was investigated. Core protein mutants were generated in which each serine was replaced with either alanine or aspartate. Aspartates can mimic constitutively phosphorylated serines while alanines can mimic constitutively dephosphorylated serines. The ability of these mutants to carry out each step of DNA synthesis was determined. Alanine substitutio ...[more]
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