Ontology highlight
ABSTRACT:
SUBMITTER: Babaei-Jadidi R
PROVIDER: S-EPMC3039859 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Babaei-Jadidi Roya R Li Ningning N Saadeddin Anas A Spencer-Dene Bradley B Jandke Anett A Muhammad Belal B Ibrahim ElSayed E EE Muraleedharan Ranjithmenon R Abuzinadah Mohammed M Davis Hayley H Lewis Annabelle A Watson Susan S Behrens Axel A Tomlinson Ian I Nateri Abdolrahman Shams AS
The Journal of experimental medicine 20110131 2
The Fbxw7 (F-box/WD repeat-containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts as a tumor suppressor in several tissues and targets multiple transcriptional activators and protooncogenes for ubiquitin-mediated degradation. To understand Fbxw7 function in the murine intestine, in this study, we specifically deleted Fbxw7 in the murine gut using Villin-Cre (Fbxw7(ΔG)). In wild-type mice, loss of Fbxw7 in th ...[more]