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Comparative analysis of organophosphate degrading enzymes from diverse species.

ABSTRACT: Different types of organophosphorous compounds constitute most potent pesticides. These chemicals attack the nervous system of living organisms causing death. Different organisms produce enzymes to degrade these chemicals. These enzymes are present in simple microorganisms from archaea, bacteria to complex eukaryotes like humans. A comparison of representative eight shortlisted enzymes involved in the degradation and inactivation of organophosphates from a wide range of organisms was performed to infer the basis of their common functionality. There is little sequence homology in these enzymes which results in divergent tertiary structures. The only feature that these enzymes seem to share is their amino acid composition. However, structural analysis has shown no significant similarities among this functionally similar group of organophosphate degrading enzymes.

SUBMITTER: Salman A

PROVIDER: S-EPMC3039992 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Comparative analysis of organophosphate degrading enzymes from diverse species.

Salman Amna A Taherian Fard Atefeh A Nasir Arshan A Bokhari Habib H

Bioinformation 20100706 2

Different types of organophosphorous compounds constitute most potent pesticides. These chemicals attack the nervous system of living organisms causing death. Different organisms produce enzymes to degrade these chemicals. These enzymes are present in simple microorganisms from archaea, bacteria to complex eukaryotes like humans. A comparison of representative eight shortlisted enzymes involved in the degradation and inactivation of organophosphates from a wide range of organisms was performed t ...[more]

PMID: 21346866

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Comparative analysis of organophosphate degrading enzymes from diverse species.

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Comparative analysis of organophosphate degrading enzymes from diverse species.

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