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Enzymology of the wood-Ljungdahl pathway of acetogenesis.

ABSTRACT: The biochemistry of acetogenesis is reviewed. The microbes that catalyze the reactions that are central to acetogenesis are described and the focus is on the enzymology of the process. These microbes play a key role in the global carbon cycle, producing over 10 trillion kilograms of acetic acid annually. Acetogens have the ability to anaerobically convert carbon dioxide and CO into acetyl-CoA by the Wood-Ljungdahl pathway, which is linked to energy conservation. They also can convert the six carbons of glucose stoichiometrically into 3 mol of acetate using this pathway. Acetogens and other anaerobic microbes (e.g., sulfate reducers and methanogens) use the Wood-Ljungdahl pathway for cell carbon synthesis. Important enzymes in this pathway that are covered in this review are pyruvate ferredoxin oxidoreductase, CO dehydrogenase/acetyl-CoA synthase, a corrinoid iron-sulfur protein, a methyltransferase, and the enzymes involved in the conversion of carbon dioxide to methyl-tetrahydrofolate.

SUBMITTER: Ragsdale SW

PROVIDER: S-EPMC3040112 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Enzymology of the wood-Ljungdahl pathway of acetogenesis.

Ragsdale Stephen W SW

Annals of the New York Academy of Sciences 20080301

The biochemistry of acetogenesis is reviewed. The microbes that catalyze the reactions that are central to acetogenesis are described and the focus is on the enzymology of the process. These microbes play a key role in the global carbon cycle, producing over 10 trillion kilograms of acetic acid annually. Acetogens have the ability to anaerobically convert carbon dioxide and CO into acetyl-CoA by the Wood-Ljungdahl pathway, which is linked to energy conservation. They also can convert the six car ...[more]

PMID: 18378591

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Enzymology of the wood-Ljungdahl pathway of acetogenesis.

Publications

Enzymology of the wood-Ljungdahl pathway of acetogenesis.

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