Ontology highlight
ABSTRACT:
SUBMITTER: Wuchty S
PROVIDER: S-EPMC3040173 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Wuchty Stefan S Arjona Dolores D Li Aiguo A Kotliarov Yuri Y Walling Jennifer J Ahn Susie S Zhang Alice A Maric Dragan D Anolik Rachel R Zenklusen Jean Claude JC Fine Howard A HA
PloS one 20110216 2
Despite progress in the determination of miR interactions, their regulatory role in cancer is only beginning to be unraveled. Utilizing gene expression data from 27 glioblastoma samples we found that the mere knowledge of physical interactions between specific mRNAs and miRs can be used to determine associated regulatory interactions, allowing us to identify 626 associated interactions, involving 128 miRs that putatively modulate the expression of 246 mRNAs. Experimentally determining the expres ...[more]