Dataset Information

Increased risk of fragility fractures among HIV infected compared to uninfected male veterans.

ABSTRACT:

Background

HIV infection has been associated with an increased risk of fragility fracture. We explored whether or not this increased risk persisted in HIV infected and uninfected men when controlling for traditional fragility fracture risk factors.

Methodology/principal findings

Cox regression models were used to assess the association of HIV infection with the risk for incident hip, vertebral, or upper arm fracture in male Veterans enrolled in the Veterans Aging Cohort Study Virtual Cohort (VACS-VC). We calculated adjusted hazard ratios comparing HIV status and controlling for demographics and other established risk factors. The sample consisted of 119,318 men, 33% of whom were HIV infected (34% aged 50 years or older at baseline, and 55% black or Hispanic). Median body mass index (BMI) was lower in HIV infected compared with uninfected men (25 vs. 28 kg/m²; p<0.0001). Unadjusted risk for fracture was higher among HIV infected compared with uninfected men [HR: 1.32 (95% CI: 1.20, 1.47)]. After adjusting for demographics, comorbid disease, smoking and alcohol abuse, HIV infection remained associated with an increased fracture risk [HR: 1.24 (95% CI: 1.11, 1.39)]. However, adjusting for BMI attenuated this association [HR: 1.10 (95% CI: 0.97, 1.25)]. The only HIV-specific factor associated with fragility fracture was current protease inhibitor use [HR: 1.41 (95% CI: 1.16, 1.70)].

Conclusions/significance

HIV infection is associated with fragility fracture risk. This risk is attenuated by BMI.

SUBMITTER: Womack JA

PROVIDER: S-EPMC3040233 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Publications

Increased risk of fragility fractures among HIV infected compared to uninfected male veterans.

Womack Julie A JA Goulet Joseph L JL Gibert Cynthia C Brandt Cynthia C Chang Chung Chou CC Gulanski Barbara B Fraenkel Liana L Mattocks Kristin K Rimland David D Rodriguez-Barradas Maria C MC Tate Janet J Yin Michael T MT Justice Amy C AC

PloS one 20110216 2

<h4>Background</h4>HIV infection has been associated with an increased risk of fragility fracture. We explored whether or not this increased risk persisted in HIV infected and uninfected men when controlling for traditional fragility fracture risk factors.<h4>Methodology/principal findings</h4>Cox regression models were used to assess the association of HIV infection with the risk for incident hip, vertebral, or upper arm fracture in male Veterans enrolled in the Veterans Aging Cohort Study Virt ...[more]

PMID: 21359191

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Dataset Information

Increased risk of fragility fractures among HIV infected compared to uninfected male veterans.

Background

Methodology/principal findings

Conclusions/significance

Publications

Increased risk of fragility fractures among HIV infected compared to uninfected male veterans.

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