Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Z
PROVIDER: S-EPMC3040460 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cheng Zhijie Z Garvin Denise D Paguio Aileen A Stecha Pete P Wood Keith K Fan Frank F
Current chemical genomics 20101221
The G protein coupled receptors (GPCR) represent the target class for nearly half of the current therapeutic drugs and remain to be the focus of drug discovery efforts. The complexity of receptor signaling continues to evolve. It is now known that many GPCRs are coupled to multiple G-proteins, which lead to regulation of respective signaling pathways downstream. Deciphering this receptor coupling will aid our understanding of the GPCR function and ultimately developing drug candidates. Here, we ...[more]