Ontology highlight
ABSTRACT:
SUBMITTER: Kotrange S
PROVIDER: S-EPMC3040464 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Kotrange Sheetal S Kopp Benjamin B Akhter Anwari A Abdelaziz Dalia D Abu Khweek Arwa A Caution Kyle K Abdulrahman Basant B Wewers Mark D MD McCoy Karen K Marsh Clay C Loutet Slade A SA Ortega Ximena X Valvano Miguel A MA Amer Amal O AO
Journal of leukocyte biology 20101222 3
Burkholderia cenocepacia infections in CF patients involve heightened inflammation, fatal sepsis, and high antibiotic resistance. Proinflammatory IL-1β secretion is important in airway inflammation and tissue damage. However, little is known about this pathway in macrophages upon B. cenocepacia infection. We report here that murine macrophages infected with B. cenocepacia K56-2 produce proinflammatory cytokine IL-1β in a TLR4 and caspase-1-mediated manner. We also determined that the OPS (O anti ...[more]