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Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial.

ABSTRACT: To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P=0.94). The day 7-day 1 factor II, R(-) and S(-) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P=0.81, P=0.45, P=0.75, respectively).Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC3040543 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial.

Zhang Qian Q   Simoneau Guy G   Verstuyft Celine C   Drouet Ludovic L   Bal dit Sollier Claire C   Alvarez Jean-Claude JC   Rizzo-Padoin Nathalie N   Bergmann Jean Francois JF   Becquemont Laurent L   Mouly Stéphane S  

British journal of clinical pharmacology 20110201 2

<h4>Aims</h4>To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.<h4>Methods</h4>In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.<h4>Results</h4>The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P=0.94). The day 7-day 1 factor II, R(-) and S  ...[more]

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