Ontology highlight
ABSTRACT:
SUBMITTER: Lepelley A
PROVIDER: S-EPMC3040675 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Lepelley Alice A Louis Stéphanie S Sourisseau Marion M Law Helen K W HK Pothlichet Julien J Schilte Clémentine C Chaperot Laurence L Plumas Joël J Randall Richard E RE Si-Tahar Mustapha M Mammano Fabrizio F Albert Matthew L ML Schwartz Olivier O
PLoS pathogens 20110217 2
Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells. We show that infected lymphocytes are more potent inducers of IFN than virions. There are target cell-type differences in the recognition of infected lymphocytes. In primary pDCs and pDC-like cells, recognition occurs in large part through TLR7, as demonstrated by the use of inhibitors and by TLR7 sil ...[more]