Novel somatic mutations in heterotrimeric G proteins in melanoma.
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ABSTRACT:
SUBMITTER: Cardenas-Navia LI
PROVIDER: S-EPMC3040832 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Novel somatic mutations in heterotrimeric G proteins in melanoma.
Cárdenas-Navia L Isabel LI Cruz Pedro P Lin Jimmy C JC Rosenberg Steven A SA Samuels Yardena Y
Cancer biology & therapy 20100701 1
Heterotrimeric guanine nucleotide-binding proteins (G proteins) mediate signals between G-protein coupled receptors and their downstream pathways, and have been shown to be mutated in cancer. In particular, GNAQ was found to be frequently mutated in blue nevi of the skin and uveal melanoma, acting as an oncogene in its mutated form. To further examine the role of heterotrimeric G proteins in malignant melanoma, we performed a comprehensive mutational analysis of the 35 genes in the heterotrimeri ...[more]
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