Dataset Information

Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.

ABSTRACT:

Background

Skeletal muscle (SM) mass decreases with advanced age and with disease in HIV infection. It is unknown whether age-related muscle loss is accelerated in the current era of antiretroviral therapy and which factors might contribute to muscle loss among HIV-infected adults. We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls.

Methods

Whole-body (1)H-magnetic resonance imaging was used to quantify regional and total SM in 399 HIV-infected and 204 control men and women at baseline and 5 years later. Multivariable regression identified associated factors.

Results

At baseline and Year 5, total SM was lower in HIV-infected than control men. HIV-infected women were similar to control women at both time points. After adjusting for demographics, lifestyle factors, and total adipose tissue, HIV infection was associated with lower Year 5 SM in men and higher SM in women compared with controls. Average overall 5-year change in total SM was small and age related, but rate of change was similar in HIV-infected and control men and women. CD4 count and efavirenz use in HIV-infected participants were associated with increasing SM, whereas age and stavudine use were associated with decreasing SM.

Conclusions

Muscle mass was lower in HIV-infected men compared with controls, whereas HIV-infected women had slightly higher SM than control women after multivariable adjustment. We found evidence against substantially faster SM decline in HIV infected versus similar-aged controls. SM gain was associated with increasing CD4 count, whereas stavudine use may contribute to SM loss.

SUBMITTER: Yarasheski KE

PROVIDER: S-EPMC3041474 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Publications

Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.

Yarasheski Kevin E KE Scherzer Rebecca R Kotler Donald P DP Dobs Adrian S AS Tien Phyllis C PC Lewis Cora E CE Kronmal Richard A RA Heymsfield Steven B SB Bacchetti Peter P Grunfeld Carl C

The journals of gerontology. Series A, Biological sciences and medical sciences 20110210 3

<h4>Background</h4>Skeletal muscle (SM) mass decreases with advanced age and with disease in HIV infection. It is unknown whether age-related muscle loss is accelerated in the current era of antiretroviral therapy and which factors might contribute to muscle loss among HIV-infected adults. We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls.<h4>Methods</h4>Whole-body (1)H-magnetic resonance imaging was used to quantify regional ...[more]

PMID: 21310810

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Dataset Information

Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.

Background

Methods

Results

Conclusions

Publications

Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.

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