Ontology highlight
ABSTRACT:
SUBMITTER: Chen R
PROVIDER: S-EPMC3041589 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Chen R R Alvero A B AB Silasi D A DA Kelly M G MG Fest S S Visintin I I Leiser A A Schwartz P E PE Rutherford T T Mor G G
Oncogene 20080414 34
Cancer progression is an abnormal form of tissue repair characterized by chronic inflammation. IkappaB kinase-beta (IKKbeta) required for nuclear factor-kappaB (NF-kappaB) activation plays a critical role in this process. Using EOC cells isolated from malignant ovarian cancer ascites and solid tumors, we identified IKKbeta as a major factor promoting a functional TLR-MyD88-NF-kappaB pathway that confers to EOC cell the capacity to constitutively secrete proinflammatory/protumor cytokines and the ...[more]