Ontology highlight
ABSTRACT:
SUBMITTER: Cardenas I
PROVIDER: S-EPMC3041595 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Cardenas Ingrid I Means Robert E RE Aldo Paulomi P Koga Kaori K Lang Sabine M SM Booth Carmen J CJ Manzur Alejandro A Oyarzun Enrique E Romero Roberto R Mor Gil G
Journal of immunology (Baltimore, Md. : 1950) 20100616 2
Pandemics pose a more significant threat to pregnant women than to the nonpregnant population and may have a detrimental effect on the well being of the fetus. We have developed an animal model to evaluate the consequences of a viral infection characterized by lack of fetal transmission. The experiments described in this work show that viral infection of the placenta can elicit a fetal inflammatory response that, in turn, can cause organ damage and potentially downstream developmental deficienci ...[more]