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A genome-wide association study of self-rated health.

ABSTRACT: Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.

SUBMITTER: Mosing MA 

PROVIDER: S-EPMC3041637 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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A genome-wide association study of self-rated health.

Mosing Miriam A MA   Verweij Karin J H KJ   Medland Sarah E SE   Painter Jodie J   Gordon Scott D SD   Heath Andrew C AC   Madden Pamela A PA   Montgomery Grant W GW   Martin Nicholas G NG  

Twin research and human genetics : the official journal of the International Society for Twin Studies 20100801 4

Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Si  ...[more]

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