Dataset Information

Propofol anesthesia and sleep: a high-density EEG study.

ABSTRACT:

Study objectives

The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.

Design

256-channel EEG recordings in humans during propofol anesthesia.

Setting

Hospital operating room.

Patients or participants

8 healthy subjects (4 males).

Interventions

N/A.

Measurements and results

Initially, propofol induced increases in EEG power from 12-25 Hz. Loss of consciousness (LOC) was accompanied by the appearance of EEG slow waves that resembled the slow waves of NREM sleep. We compared slow waves in propofol to slow waves recorded during natural sleep and found that both populations of waves share similar cortical origins and preferentially propagate along the mesial components of the default network. However, propofol slow waves were spatially blurred compared to sleep slow waves and failed to effectively entrain spindle activity. Propofol also caused an increase in gamma (25-40 Hz) power that persisted throughout LOC. Source modeling analysis showed that this increase in gamma power originated from the anterior and posterior cingulate cortices. During LOC, we found increased gamma functional connectivity between these regions compared to the wakefulness.

Conclusions

Propofol anesthesia is a sleep-like state and slow waves are associated with diminished consciousness even in the presence of high gamma activity.

SUBMITTER: Murphy M

PROVIDER: S-EPMC3041704 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Publications

Propofol anesthesia and sleep: a high-density EEG study.

Murphy Michael M Bruno Marie-Aurélie MA Riedner Brady A BA Boveroux Pierre P Noirhomme Quentin Q Landsness Eric C EC Brichant Jean-Francois JF Phillips Christophe C Massimini Marcello M Laureys Steven S Tononi Giulio G Boly Mélanie M

Sleep 20110301 3

<h4>Study objectives</h4>The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.<h4>Design</h4>256-channel EEG recordings in humans during propofol anesthesia.<h4>Setting</h4>Hospital operating room.<h4>Patients or participants</h4>8 healthy subjects (4 males).<h4>Interventions</h4>N/A.<h4>Measurement ...[more]

PMID: 21358845

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Project description:BackgroundPhase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth monitoring using PLE and to evaluate the correlation between PLE and bispectral index (BIS) values during propofol anesthesia.MethodsIn thirty-five adult patients undergoing elective surgery, anesthesia was induced with propofol using target-controlled infusion (the Schneider model). We recorded the PLE value, raw EEG, BIS value, and hemodynamic data when the target effect-site concentration (Ce) of propofol reached 2, 3, 4, 5, and 6??g/ml before intubation and 6, 5, 4, 3, 2??g/ml after intubation and injection of muscle relaxant. We analyzed whether PLE and raw EEG data from the PLE monitor reflected the anesthetic depth as the Ce of propofol changed, and whether PLE values were comparable to BIS values.ResultsPLE values were inversely correlated to changes in propofol Ce (propofol Ce from 0 to 6.0??g/ml, r2?=?-?0.83; propofol Ce from 6.0 to 2.0??g/ml, r2?=?-?0.46). In the spectral analysis of EEG acquired from the PLE monitor, the persistence spectrogram revealed a wide distribution of power at loss of consciousness (LOC) and recovery of consciousness (ROC), with a narrow distribution during unconsciousness. The power spectrogram showed the typical pattern seen in propofol anesthesia with slow alpha frequency band oscillation. The PLE value demonstrated a strong correlation with the BIS value during the change in propofol Ce from 0 to 6.0??g/ml (r2?=?0.84). PLE and BIS values were similar at LOC (62.3 vs. 61.8) (P?>?0.05), but PLE values were smaller than BIS values at ROC (64.4 vs 75.7) (P?<?0.05).ConclusionsThe PLE value is a useful anesthetic depth indicator, similar to the BIS value, during propofol anesthesia. Spectral analysis of EEG acquired from the PLE monitor demonstrated the typical patterns seen in propofol anesthesia.Trial registrationThis clinical trial was retrospectively registered at ClinicalTrials.gov at October 2017 (NCT03299621).

Dataset Information

Propofol anesthesia and sleep: a high-density EEG study.

Study objectives

Design

Setting

Patients or participants

Interventions

Measurements and results

Conclusions

Publications

Propofol anesthesia and sleep: a high-density EEG study.

Similar Datasets

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