Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis.

ABSTRACT:

Background

Observational studies and randomized controlled trials have yielded inconsistent findings about the association between the use of acid-suppressive drugs and the risk of pneumonia. We performed a systematic review and meta-analysis to summarize this association.

Methods

We searched three electronic databases (MEDLINE [PubMed], Embase and the Cochrane Library) from inception to Aug. 28, 2009. Two evaluators independently extracted data. Because of heterogeneity, we used random-effects meta-analysis to obtain pooled estimates of effect.

Results

We identified 31 studies: five case-control studies, three cohort studies and 23 randomized controlled trials. A meta-analysis of the eight observational studies showed that the overall risk of pneumonia was higher amo

SUBMITTER: Eom CS 

PROVIDER: S-EPMC3042441 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature