Allosteric response is both conserved and variable across three CheY orthologs.
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ABSTRACT:
SUBMITTER: Mottonen JM
PROVIDER: S-EPMC3042579 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Allosteric response is both conserved and variable across three CheY orthologs.
Mottonen James M JM Jacobs Donald J DJ Livesay Dennis R DR
Biophysical journal 20101001 7
A computational method to identify residues likely to initiate allosteric signals has been developed. The method is based on differences within stability and flexibility profiles between wild-type and perturbed structures as computed by a distance constraint model. Application of the approach to three bacterial chemotaxis protein Y (CheY) orthologs provides a comparison of allosteric response across protein family divergence. Interestingly, we observe a rich mixture of both conservation and vari ...[more]
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