Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach.
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ABSTRACT:
SUBMITTER: Edwards YJ
PROVIDER: S-EPMC3043094 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach.
Edwards Yvonne J K YJ Beecham Gary W GW Scott William K WK Khuri Sawsan S Bademci Guney G Tekin Demet D Martin Eden R ER Jiang Zhijie Z Mash Deborah C DC ffrench-Mullen Jarlath J Pericak-Vance Margaret A MA Tsinoremas Nicholas N Vance Jeffery M JM
PloS one 20110222 2
Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p<0.01) from a joint analysis of three existing PD GWAS were identified and each assigned to a gene. For gene expression, rather than the traditional comparison ...[more]
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