Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels.
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ABSTRACT:
SUBMITTER: Baek JH
PROVIDER: S-EPMC3043121 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels.
Baek Je-Hyun JH Cerda Oscar O Trimmer James S JS
Seminars in cell & developmental biology 20101012 2
Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity ...[more]
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