Cortical DNA methylation maintains remote memory.
Ontology highlight
ABSTRACT:
SUBMITTER: Miller CA
PROVIDER: S-EPMC3043549 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Cortical DNA methylation maintains remote memory.
Miller Courtney A CA Gavin Cristin F CF White Jason A JA Parrish R Ryley RR Honasoge Avinash A Yancey Christopher R CR Rivera Ivonne M IM Rubio María D MD Rumbaugh Gavin G Sweatt J David JD
Nature neuroscience 20100523 6
A behavioral memory's lifetime represents multiple molecular lifetimes, suggesting the necessity for a self-perpetuating signal. One candidate is DNA methylation, a transcriptional repression mechanism that maintains cellular memory throughout development. We found that persistent, gene-specific cortical hypermethylation was induced in rats by a single, hippocampus-dependent associative learning experience and pharmacologic inhibition of methylation 1 month after learning disrupted remote memory ...[more]
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