Ontology highlight
ABSTRACT:
SUBMITTER: Arsenault D
PROVIDER: S-EPMC3044176 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Arsenault Dany D Julien Carl C Tremblay Cyntia C Calon Frédéric F
PloS one 20110223 2
Defects in neuronal activity of the entorhinal cortex (EC) are suspected to underlie the symptoms of Alzheimer's disease (AD). Whereas neuroprotective effects of docosahexaenoic acid (DHA) have been described, the effects of DHA on the physiology of EC neurons remain unexplored in animal models of AD. Here, we show that DHA consumption improved object recognition (↑12%), preventing deficits observed in old 3xTg-AD mice (↓12%). Moreover, 3xTg-AD mice displayed seizure-like akinetic episodes, not ...[more]