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The integration of negative affect, pain and cognitive control in the cingulate cortex.

ABSTRACT: It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view. Imaging studies demonstrate that negative affect, pain and cognitive control activate an overlapping region of the dorsal cingulate--the anterior midcingulate cortex (aMCC). Anatomical studies reveal that the aMCC constitutes a hub where information about reinforcers can be linked to motor centres responsible for expressing affect and executing goal-directed behaviour. Computational modelling and other kinds of evidence suggest that this intimacy reflects control processes that are common to all three domains. These observations compel a reconsideration of the dorsal cingulate's contribution to negative affect and pain.

SUBMITTER: Shackman AJ

PROVIDER: S-EPMC3044650 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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The integration of negative affect, pain and cognitive control in the cingulate cortex.

Shackman Alexander J AJ Salomons Tim V TV Slagter Heleen A HA Fox Andrew S AS Winter Jameel J JJ Davidson Richard J RJ

Nature reviews. Neuroscience 20110301 3

It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view. Imaging studies demonstrate that negative affect, pain and cognitive control activate an overlapping region of the dorsal cingulate--the anterior midcingulate cortex (aMCC). Anatomical studies reveal that the aMCC constitutes a hub where information about reinforcers can be linked to motor ...[more]

PMID: 21331082

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