Exploring the evolutionary relationship of insulin receptor substrate family using computational biology.
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ABSTRACT:
SUBMITTER: Chakraborty C
PROVIDER: S-EPMC3045367 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Exploring the evolutionary relationship of insulin receptor substrate family using computational biology.
Chakraborty Chiranjib C Agoramoorthy Govindasamy G Hsu Minna J MJ
PloS one 20110225 2
Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algorithm analysis and mathematical models. ...[more]
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