Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC3045591 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Chen Cuie C Pu Fang F Huang Zhenzhen Z Liu Zhen Z Ren Jinsong J Qu Xiaogang X
Nucleic acids research 20101021 4
A novel proton-fueled molecular gate-like delivery system has been constructed for controlled cargo release using i-motif quadruplex DNA as caps onto pore outlets of mesoporous silica nanoparticles. Start from simple conformation changes, the i-motif DNA cap can open and close the pore system in smart response to pH stimulus. Importantly, the opening/closing and delivery protocol is highly reversible and a partial cargo delivery can be easily controlled at will. A pH-switchable nanoreactor has a ...[more]