Ontology highlight
ABSTRACT:
SUBMITTER: Braglia P
PROVIDER: S-EPMC3045592 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Braglia Priscilla P Kawauchi Junya J Proudfoot Nick J NJ
Nucleic acids research 20101023 4
Ribosomal RNA, transcribed by RNA polymerase (Pol) I, accounts for most cellular RNA. Since Pol I transcribes rDNA repeats with high processivity and polymerase density, transcription termination is a critical process. Early in vitro studies proposed polymerase pausing by Reb1 and transcript release at the T-rich element T1 determined transcription termination. However recent in vivo studies revealed a 'torpedo' mechanism for Pol I termination: co-transcriptional RNA cleavage by Rnt1 provides an ...[more]