Ontology highlight
ABSTRACT:
SUBMITTER: Crona M
PROVIDER: S-EPMC3045599 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Crona Mikael M Moffatt Connor C Friedrich Nancy C NC Hofer Anders A Sjöberg Britt-Marie BM Edgell David R DR
Nucleic acids research 20101023 4
Ribonucleotide reductase (RNR) is a critical enzyme of nucleotide metabolism, synthesizing precursors for DNA replication and repair. In prokaryotic genomes, RNR genes are commonly targeted by mobile genetic elements, including free standing and intron-encoded homing endonucleases and inteins. Here, we describe a unique molecular solution to assemble a functional product from the RNR large subunit gene, nrdA that has been fragmented into two smaller genes by the insertion of mobE, a mobile endon ...[more]