Ontology highlight
ABSTRACT:
SUBMITTER: Feagins AR
PROVIDER: S-EPMC3045649 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Feagins Alicia R AR Córdoba Laura L Sanford Brent J BJ Dryman Barbara A BA Huang Yao-Wei YW LeRoith Tanya T Emerson Suzanne U SU Meng Xiang-Jin XJ
Virus research 20101230 1-2
Genotypes 1 and 2 hepatitis E virus (HEV) infect only humans whereas genotypes 3 and 4 HEV infect both humans and pigs. To evaluate the mechanism of cross-species HEV infection between humans and swine, in this study we constructed five intergenotypic chimeric viruses and tested for their infectivity in vitro and in pigs. We demonstrated that chimeric viruses containing the ORF2 capsid gene either alone or in combination with its adjacent 5' junction region (JR) and 3' noncoding region (NCR) fro ...[more]