Pooled versus individual genotyping in a breast cancer genome-wide association study.
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ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC3045656 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Pooled versus individual genotyping in a breast cancer genome-wide association study.
Huang Ying Y Hinds David A DA Qi Lihong L Prentice Ross L RL
Genetic epidemiology 20100901 6
We examine the measurement properties of pooled DNA odds ratio estimates for 7,357 single nucleotide polymorphisms (SNPs) genotyped in a genome-wide association study of postmenopausal breast cancer. This study involved DNA pools formed from 125 cases or 125 matched controls. Individual genotyping for these SNPs subsequently came available for a substantial majority of women included in seven pool pairs, providing the opportunity for a comparison of pooled DNA and individual odds ratio estimates ...[more]
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