Ontology highlight
ABSTRACT:
SUBMITTER: Ferreira EN
PROVIDER: S-EPMC3045797 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
BMC genomics 20101222
<h4>Background</h4>Alternative splicing (AS) is a central mechanism in the generation of genomic complexity and is a major contributor to transcriptome and proteome diversity. Alterations of the splicing process can lead to deregulation of crucial cellular processes and have been associated with a large spectrum of human diseases. Cancer-associated transcripts are potential molecular markers and may contribute to the development of more accurate diagnostic and prognostic methods and also serve a ...[more]