Modeling endotoxin-induced systemic inflammation using an indirect response approach.

ABSTRACT: A receptor mediated model of endotoxin-induced human inflammation is proposed. The activation of the innate immune system in response to the endotoxin stimulus involves the interaction between the extracellular signal and critical receptors driving downstream signal transduction cascades leading to transcriptional changes. We explore the development of an in silico model that aims at coupling extracellular signals with essential transcriptional responses through a receptor mediated indirect response model. The model consists of eight (8) variables and is evaluated in a series of biologically relevant scenarios indicative of the non-linear behavior of inflammation. Such scenarios involve a self-limited response where the inflammatory stimulus is cleared successfully; a persistent infectious

SUBMITTER: Foteinou PT 

PROVIDER: S-EPMC3045970 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature