Ontology highlight
ABSTRACT:
SUBMITTER: Jakawich SK
PROVIDER: S-EPMC3046391 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Jakawich Sonya K SK Nasser Hassan B HB Strong Michael J MJ McCartney Amber J AJ Perez Amanda S AS Rakesh Neal N Carruthers Cynthia J L CJ Sutton Michael A MA
Neuron 20101201 6
Homeostatic synaptic plasticity is important for maintaining stability of neuronal function, but heterogeneous expression mechanisms suggest that distinct facets of neuronal activity may shape the manner in which compensatory synaptic changes are implemented. Here, we demonstrate that local presynaptic activity gates a retrograde form of homeostatic plasticity induced by blockade of AMPA receptors (AMPARs) in cultured hippocampal neurons. We show that AMPAR blockade produces rapid (<3 hr) protei ...[more]