Ontology highlight
ABSTRACT:
SUBMITTER: Waite CL
PROVIDER: S-EPMC3047462 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Waite Carolyn L CL Roth Charles M CM
Bioconjugate chemistry 20090923 10
Generation 5 poly(amidoamine) (PAMAM) dendrimers were modified by the addition of cyclic RGD targeting peptides and were evaluated for their ability to associate with siRNA and mediate siRNA delivery to U87 malignant glioma cells. PAMAM-RGD conjugates were able to complex with siRNA to form complexes of approximately 200 nm in size. Modest siRNA delivery was observed in U87 cells using either PAMAM or PAMAM-RGD conjugates. PAMAM-RGD conjugates prevented the adhesion of U87 cells to fibrinogen-co ...[more]