Rapid cellular turnover in adipose tissue.
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ABSTRACT:
SUBMITTER: Rigamonti A
PROVIDER: S-EPMC3047582 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Rapid cellular turnover in adipose tissue.
Rigamonti Alessandra A Brennand Kristen K Lau Frank F Cowan Chad A CA
PloS one 20110302 3
It was recently shown that cellular turnover occurs within the human adipocyte population. Through three independent experimental approaches--dilution of an inducible histone 2B-green fluorescent protein (H2BGFP), labeling with the cell cycle marker Ki67 and incorporation of BrdU--we characterized the degree of cellular turnover in murine adipose tissue. We observed rapid turnover of the adipocyte population, finding that 4.8% of preadipocytes are replicating at any time and that between 1-5% of ...[more]
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