Fear-conditioning mechanisms associated with trait vulnerability to anxiety in humans.
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ABSTRACT:
SUBMITTER: Indovina I
PROVIDER: S-EPMC3047792 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Fear-conditioning mechanisms associated with trait vulnerability to anxiety in humans.
Indovina Iole I Robbins Trevor W TW Núñez-Elizalde Anwar O AO Dunn Barnaby D BD Bishop Sonia J SJ
Neuron 20110201 3
Investigations of fear conditioning in rodents and humans have illuminated the neural mechanisms underlying cued and contextual fear. A critical question is how personality dimensions such as trait anxiety act through these mechanisms to confer vulnerability to anxiety disorders, and whether humans' ability to overcome acquired fears depends on regulatory skills not characterized in animal models. In a neuroimaging study of fear conditioning in humans, we found evidence for two independent dimen ...[more]
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