Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial.

ABSTRACT:

Context

Concern exists that androgen treatment might adversely impact prostate health in older men. Dihydrotestosterone (DHT), derived from local conversion of testosterone to DHT by 5α-reductase enzymes, is the principal androgen within the prostate. Exogenous androgens raise serum DHT concentrations, but their effects on the prostate are not clear.

Objective

To determine the impact of large increases in serum DHT concentrations on intraprostatic androgen concentrations and androgen action within the prostate.

Design

Double-blind, randomized, placebo-controlled.

Setting

Single academic medical center.

Participants

31 healthy men ages 35-55.

Intervention

Daily transdermal DHT or placebo gel.

Main outcome measures

Serum and prostate tissue a

SUBMITTER: Page ST 

PROVIDER: S-EPMC3048323 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature