Ontology highlight
ABSTRACT:
SUBMITTER: Edderkaoui M
PROVIDER: S-EPMC3048665 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20101130 10
We recently showed that Nox4 NADPH oxidase is highly expressed in pancreatic ductal adenocarcinoma and that it is activated by growth factors and plays a pro-survival, anti-apoptotic role. Here we investigate the mechanisms through which insulin-like growth factor I and serum (FBS) activate NADPH oxidase in pancreatic cancer (PaCa) cells. We show that in PaCa cells, NADPH oxidase is composed of Nox4 and p22(phox) catalytic subunits, which are both required for NADPH oxidase activity. Insulin-lik ...[more]