Ontology highlight
ABSTRACT:
SUBMITTER: Xiao L
PROVIDER: S-EPMC3048666 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Xiao Ling L Chen Yuanhong Y Ji Ming M Dong Jixin J
The Journal of biological chemistry 20110113 10
The Hippo pathway controls tissue growth and tumorigenesis by inhibiting cell proliferation and promoting apoptosis. Recent genetic studies in Drosophila identified Kibra as a novel regulator of Hippo signaling. Human KIBRA has been associated with memory performance and cell migration. However, it is unclear whether or how KIBRA is connected to the Hippo pathway in mammalian cells. Here, we show that KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulatin ...[more]