Ontology highlight
ABSTRACT:
SUBMITTER: Acevedo KM
PROVIDER: S-EPMC3048711 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Acevedo Karla M KM Hung Ya Hui YH Dalziel Andrew H AH Li Qiao-Xin QX Laughton Katrina K Wikhe Krutika K Rembach Alan A Roberts Blaine B Masters Colin L CL Bush Ashley I AI Camakaris James J
The Journal of biological chemistry 20101222 10
Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (APP). We reported previously that copper increases the level of APP at the cell surface. Here we report that copper, but not iron or zinc, promotes APP trafficking in cultured polarized epithelial cells and neuronal cells. In SH-SY5Y neuronal cells and ...[more]