Immunohistochemical expression of BRCA1 and lethal prostate cancer.
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ABSTRACT:
SUBMITTER: Fiorentino M
PROVIDER: S-EPMC3049266 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Immunohistochemical expression of BRCA1 and lethal prostate cancer.
Fiorentino Michelangelo M Judson Gregory G Penney Kathryn K Flavin Richard R Stark Jennifer J Fiore Christopher C Fall Katja K Martin Neil N Ma Jing J Sinnott Jennifer J Giovannucci Edward E Stampfer Meir M Sesso Howard D HD Kantoff Philip W PW Finn Stephen S Loda Massimo M Mucci Lorelei L
Cancer research 20100413 8
BRCA1 functions as a tumor suppressor; recent work suggests that BRCA1 may also induce cell cycle arrest to allow for DNA repair. We hypothesized that BRCA1 expression in prostate tumor tissue may be associated with prostate cancer progression through regulation of the cell cycle. We used immunohistochemistry to evaluate BRCA1 protein expression in archival tumor samples from 393 prostate cancer cases in the Physicians' Health Study. The men were followed prospectively from diagnosis to developm ...[more]
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