Ontology highlight
ABSTRACT:
SUBMITTER: Oki M
PROVIDER: S-EPMC3049324 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Oki Mie M Watanabe Norihiko N Owada Takayoshi T Oya Yoshihiro Y Ikeda Kei K Saito Yasushi Y Matsumura Ryutaro R Seto Yohei Y Iwamoto Itsuo I Nakajima Hiroshi H
Clinical & developmental immunology 20110222
Inhibitory coreceptors are thought to play important roles in maintaining immunological homeostasis, and a defect in the negative signals from inhibitory coreceptors may lead to the development of autoimmune diseases. We have recently identified B and T lymphocyte attenuator (BTLA), a new inhibitory coreceptor expressed on immune cells, and we suggest that BTLA may be involved in the development of autoimmune diseases using BTLA-deficient mice. However, the role of BTLA in the pathogenesis of au ...[more]