Ontology highlight
ABSTRACT:
SUBMITTER: Feng S
PROVIDER: S-EPMC3049426 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Feng Siqian S Huang Jianhua J Wang Jian J
EMBO reports 20101217 2
Polycomb group (PcG) proteins are conserved epigenetic regulators that are linked to cancer in humans. However, little is known about how they control cell proliferation. Here, we report that mutant clones of the PcG gene polyhomeotic (ph) form unique single-cell-layer cavities that secrete three JAK/STAT pathway ligands, which in turn act redundantly to stimulate overproliferation of surrounding wild-type cells. Notably, different ph alleles cause different phenotypes at the cellular level. Alt ...[more]