Ontology highlight
ABSTRACT:
SUBMITTER: McLean JR
PROVIDER: S-EPMC3049645 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
McLean Janel R JR Kouranti Ilektra I Gould Kathleen L KL
Journal of proteome research 20110204 3
Ubiquitination plays a role in virtually every cellular signaling pathway ranging from cell cycle control to DNA damage response to endocytosis and gene regulation. The bulk of our knowledge of the ubiquitination system is centered on modification of specific substrate proteins and the enzymatic cascade of ubiquitination. Our understanding of the regulation of the reversal of these modifications (deubiquitination) lags significantly behind. We recently reported a multifaceted study of the fissio ...[more]