Ontology highlight
ABSTRACT:
SUBMITTER: Rottmann M
PROVIDER: S-EPMC3050001 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Rottmann Matthias M McNamara Case C Yeung Bryan K S BK Lee Marcus C S MC Zou Bin B Russell Bruce B Seitz Patrick P Plouffe David M DM Dharia Neekesh V NV Tan Jocelyn J Cohen Steven B SB Spencer Kathryn R KR González-Páez Gonzalo E GE Lakshminarayana Suresh B SB Goh Anne A Suwanarusk Rossarin R Jegla Timothy T Schmitt Esther K EK Beck Hans-Peter HP Brun Reto R Nosten Francois F Renia Laurent L Dartois Veronique V Keller Thomas H TH Fidock David A DA Winzeler Elizabeth A EA Diagana Thierry T TT
Science (New York, N.Y.) 20100901 5996
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates at low nanomolar concentration. Spiroindolones rapidly inhibit protein synthesis in P. falciparum, an effect that is ablated in parasites bearing nonsynonymous mutations in the ge ...[more]