Ontology highlight
ABSTRACT:
SUBMITTER: Viswanathan J
PROVIDER: S-EPMC3050036 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Viswanathan Jayashree J Haapasalo Annakaisa A Böttcher Claudia C Miettinen Riitta R Kurkinen Kaisa M A KM Lu Alice A Thomas Anne A Maynard Christa J CJ Romano Donna D Hyman Bradley T BT Berezovska Oksana O Bertram Lars L Soininen Hilkka H Dantuma Nico P NP Tanzi Rudolph E RE Hiltunen Mikko M
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The Alzheimer's disease (AD)-associated ubiquilin-1 regulates proteasomal degradation of proteins, including presenilin (PS). PS-dependent γ-secretase generates β-amyloid (Aβ) peptides, which excessively accumulate in AD brain. Here, we have characterized the effects of naturally occurring ubiquilin-1 transcript variants (TVs) on the levels and subcellular localization of PS1 and other γ-secretase complex components and subsequent γ-secretase function in human embryonic kidney 293, human neurobl ...[more]