Ontology highlight
ABSTRACT:
SUBMITTER: Joyasawal S
PROVIDER: S-EPMC3050037 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Organic letters 20100301 5
The synthesis of a C1-C19 precursor to pectenotoxin 4 is presented. The strategy employed the functionalized allene shown. Key features include: olefin metathesis of two simple fragments to prepare the left portion of the allene-precursor, diastereoselective propargylation of an epoxy aldehyde to form the right portion, use of the DMDO-stable m-fluorobenzyl ether, and an allene spirodiepoxidation/C-ring formation cascade. ...[more]