A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.
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ABSTRACT:
SUBMITTER: Fish JE
PROVIDER: S-EPMC3050667 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.
Fish Jason E JE Wythe Joshua D JD Xiao Tong T Bruneau Benoit G BG Stainier Didier Y R DY Srivastava Deepak D Woo Stephanie S
Development (Cambridge, England) 20110401 7
Members of the Slit family of secreted ligands interact with Roundabout (Robo) receptors to provide guidance cues for many cell types. For example, Slit/Robo signaling elicits repulsion of axons during neural development, whereas in endothelial cells this pathway inhibits or promotes angiogenesis depending on the cellular context. Here, we show that miR-218 is intronically encoded in slit2 and slit3 and that it suppresses Robo1 and Robo2 expression. Our data indicate that miR-218 and multiple Sl ...[more]
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